The acquisition of scientific skills for the application of evidence-based practice (EBP) is considered an essential part of health education programmes to improve clinical effectiveness. An examination of the scientific skills of occupational therapists can be useful in understanding their current practice, as well as providing a basis for applying appropriate approaches to the development and implementation of EBP. Therefore, this study was designed with two main objectives: (1) to describe the level of scientific skills acquisition and academic performance in Spanish-speaking occupational therapists; (2) to examine the factors associated with these skills. The Scientific Skills Screening for Occupational Therapists, HACTO-Screen, is a cross-sectional online survey divided into five sections: sociodemographic data, academic and professional background; assessment of scientific skills; training and development needs in research; experience as a researcher and/or academic.